| 2024 | The Street Avenger | Muerte |
| 2024 | Detour 95 | Muerte |
| 2024 | Seven Cemeteries | Bravo |
| 2024 | Holy Cash | Actor |
| 2024 | The Legend of Johnny Jones | El Muerte |
| 2024 | I Heart Robots | Bob |
| 2024 | Mr. Birchum (serie) | Switchblade (voice) |
| 2024 | Gracie and Pedro: Pets to the Rescue | Laurence (voice) |
| 2024 | Tim Travers & the Time Travelers Paradox | Royce |
| 2024 | La noche que volvimos a casa | Digger |
| 2023 | Miami Bici 2 | Mr Susan |
| 2023 | Death on the Border | Father Francis |
| 2023 | 1521: The Quest for Love and Freedom | Ferdinand Magellan |
| 2023 | Una preghiera per Giuda | Carnizzari |
| 2023 | Hunting Games | Sheriff Ramos |
| 2023 | Los Muppets: Los Mayhem dan la nota (serie) | Danny Trejo |
| 2023 | The Dream Americano | Self |
| 2022 | Desfase en Navidad | Angel |
| 2022 | Renegades | Sanchez |
| 2022 | Lopez vs Lopez (serie) | — |
| 2022 | Fire-Man's Fetish | Fire-Man |
| 2022 | Wolf Mountain | Eddie |
| 2022 | Chibiverse (serie) | Vasquez (voice) |
| 2022 | Smile or Hug | — |
| 2022 | Caroltyn | Wells |
| 2022 | Iron Chef: La Leyenda de Hierro (serie) | Self - Guest Judge |
| 2022 | Escándalo Secreto En Plena Cuarentena | MMR, Mario Machin Rin |
| 2022 | PBC (serie) | Ricky |
| 2022 | VampFather | Vampfather |
| 2021 | El libro de Boba Fett (serie) | Rancor Keeper |
| 2021 | American Sicario | Pedro |
| 2021 | Pups Alone | Vinnie P (voice) |
| 2021 | Comedy Chingonas | Self - Host |
| 2021 | Maya y los tres (serie) | Cabrakan (voice) |
| 2021 | La maldición de Molly McGee (serie) | Bobby Daniels (voice) |
| 2021 | Death Rider in the House of Vampires | Bela Latigo |
| 2021 | La sombra del gato | Sombra |
| 2021 | Masters del Universo: Revelación (serie) | Ram Man (voice) |
| 2021 | The Rebels of PT-218 | Seaman Edgar 'Cookie' Orozco |
| 2021 | American Horror Stories (serie) | Santa |
| 2021 | Monstruos a la obra (serie) | Terry (voice) |
| 2020 | La Última Exorcista | Marco |
| 2020 | Lumpia: With a Vengeance | Reyes |
| 2020 | Final Kill | Francesco |
| 2020 | Pistolera | Indio |
| 2020 | Más Muppets que nunca (serie) | Self |
| 2020 | Bullets of Justice | Gravedigger |
| 2019 | Fast & Furious: Espías a todo gas (serie) | Tuco (voice) |
| 2019 | Acceleration. Velocidad asesina | Santos |
| 2019 | Black Licorice | Donicio |
| 2019 | Seis Manos (serie) | Baldemar / El Balde (voice) |
| 2019 | Madness in the Method | Danny |
| 2019 | Bare Knuckle Brawler | Santo Ariza |
| 2019 | Recluso nº 1: la redención de Danny Trejo | Self |
| 2019 | El programa de Kelly Clarkson (serie) | Self |
| 2019 | The Margarita Man | Dr. Valenzuela |
| 2019 | Lights Out with David Spade (serie) | Self |
| 2019 | Wish Man | Jose |
| 2019 | Every 9 Hours | Raul |
| 2019 | L.A.'s Finest. Policías de Los Ángeles (serie) | Reuben Velazquez |
| 2019 | The Short History of the Long Road | Miguel |
| 2019 | Theme Song Takeover (serie) | Vasquez (voice) |
| 2019 | Victor y Valentino (serie) | Paco (voice) |
| 2019 | Lo que hacemos en las sombras (serie) | Danny |
| 2019 | Counterpunch | Manny Navarro |
| 2019 | Grand-Daddy Day Care | Eduardo Hernandez |
| 2019 | Mask Singer: Adivina quién canta (Estados Unidos) (serie) | Raccoon |
| 2018 | Los Conners (serie) | Tito |
| 2018 | Death Race: Beyond Anarchy | Goldberg |
| 2018 | Silencer | Lenard "Big Daddy" Ochoa |
| 2018 | Frat Pack | Dirty |
| 2018 | Los Green en la gran ciudad (serie) | Vasquez (voice) |
| 2018 | Fury of the Fist and the Golden Fleece | Nino Grande |
| 2018 | Roxy | Principal Castillo |
| 2018 | Gone Are the Days | River Man |
| 2018 | La guía de los supervivientes de la prisión | Self |
| 2017 | Venganza criminal: La leyenda de la loca | Antonio |
| 2017 | McDick | Oscar |
| 2017 | Más Muerte en Tombstone | Guerrero |
| 2017 | All About The Money | Luis Diego |
| 2017 | American Gods (serie) | Mr. World |
| 2017 | Juarez 2045 | Angel Malvado |
| 2017 | Cross Wars | Murete |
| 2016 | Chronology | Jackhammer |
| 2016 | El escuadrón vigilante | Crazy Joe |
| 2016 | 1st Strike | Manny Garcia |
| 2016 | Range 15 | Zombie Trejo |
| 2016 | Map of Hell | Himself |
| 2016 | Bridesman | Eduardo |
| 2016 | Cyborg X | Captain Machine Gun |
| 2016 | Boost | Roy Casares |
| 2016 | Angie Tribeca (serie) | Himself |
| 2016 | North by El Norte | Uncle John |
| 2015 | Real Rob (serie) | Danny |
| 2015 | Sock 'Em Dead | Self - Host |
| 2015 | The New Looney Tunes (serie) | Lieutenant (voice) |
| 2015 | Los olvidados | Mateo Perez |
| 2015 | The Late Show with Stephen Colbert (serie) | — |
| 2015 | East LA Interchange | narrator |
| 2015 | El ataque del tiburón de tres cabezas | Max Burns |
| 2015 | Cerdo, Cabra, Banana, Grillo (serie) | Filthy the Foot (voice) |
| 2015 | The Weight of Blood and Bones | Espada |
| 2015 | Soldado de la noche | Aguilar |
| 2015 | Alcatraz Prison Escape: Deathbed Confession | Narrator (voice) |
| 2015 | Un tipo duro 3: En el pantano | Frank Vega |
| 2015 | VANish | Carlos |
| 2015 | The Burning Dead | Night Wolf |
| 2015 | Hope Lost | Marius |
| 2015 | A Horse Story | Moonlight (voice) |
| 2014 | Beyond the Game | José |
| 2014 | El Juego De La Justicia | Tattoo |
| 2014 | Strike One | Manny Garcia |
| 2014 | Misfit Garage (serie) | — |
| 2014 | The Flash (serie) | Breacher |
| 2014 | Reaper | Jack |
| 2014 | Preggoland | Pedro |
| 2014 | Famosos en peligro con Bear Grylls (serie) | Self |
| 2014 | Tipos duros | Frank Vega |
| 2014 | 20 Ft Below: The Darkness Descending | Angel |
| 2014 | Camino hacia el éxito | Vic |
| 2014 | Abierto hasta el amanecer (serie) | The Regulator |
| 2014 | Saint George (serie) | Tio |
| 2014 | Ejecución extrema | Oso |
| 2014 | Posesión vudú | Kross |
| 2013 | The Insomniac | Jairo Torres |
| 2013 | Rick y Morty (serie) | Jaguar (voice) |
| 2013 | Muerte en Tombstone | Guerrero |
| 2013 | Brooklyn Nine-Nine (serie) | Oscar Diaz |
| 2013 | Chavez Cage of Glory | Mando |
| 2013 | Machete Kills | Machete Cortez |
| 2013 | Pendejo | Pedro |
| 2013 | Zombie Hunter | Jesús |
| 2013 | Amelia's 25th | Don Javier |
| 2013 | Mickey Mouse (serie) | Piñata Boss (voice) |
| 2013 | Five Thirteen | El Loco |
| 2013 | Anthony Bourdain: Parts Unknown (serie) | Self |
| 2013 | Tattoo Nation | Himself |
| 2013 | Circus Halligalli (serie) | — |
| 2013 | Death Race 3 (La carrera de la muerte: Inferno) | Goldberg |
| 2012 | Mango Bajito | Carson |
| 2012 | Sushi Girl | Schlomo |
| 2012 | The Cloth | Father Connely |
| 2012 | Rise of the Zombies | Caspian |
| 2012 | Escuela Embrujada | Ortiz |
| 2012 | Recoil | Drayke |
| 2012 | Tipo duro | Frank Vega |
| 2011 | In the Shadow | Hermit |
| 2011 | China, IL (serie) | (voice) |
| 2011 | The Black Mamba | The Crippler |
| 2011 | Violet & Daisy | Russ |
| 2011 | Poolboy: Drowning Out the Fury | Ceasar |
| 2011 | House of the Rising Sun | Carlos |
| 2011 | Dark Games | Archie |
| 2011 | Cross | Lexavier |
| 2011 | Blacktino | Rogelio |
| 2010 | La joven Liga de la Justicia (serie) | Bane (voice) |
| 2010 | Death Race 2 (La carrera de la muerte: El origen) | Goldberg |
| 2010 | Predators: Moments of Extraction | Cuchillo (Voice) |
| 2010 | Predators: The Chosen | Cuchillo |
| 2010 | Modus Operandi | Director Holiday |
| 2010 | The Bill Collector | Frankie Gutierrez |
| 2010 | Machete | Machete |
| 2010 | Beatdown | Marcus |
| 2010 | Predators | Cuchillo |
| 2010 | Pastor Shepherd | Phil Harrison |
| 2010 | Asesinos al amanecer | Jimmy |
| 2010 | Shadows in Paradise | Matador |
| 2010 | Boston Girls | Uncle Reggie |
| 2010 | Justin Time | Mardok |
| 2010 | The Lazarus Papers | Aroon |
| 2010 | American Flyer | Uncle John |
| 2010 | Matad al heroe | Crazy Joe |
| 2009 | Cuidado con las niñeras | Clyde / The Guard |
| 2009 | Modern Family (serie) | Gus |
| 2009 | The Grind | Nicholi Guzman |
| 2009 | NCIS: Los Ángeles (serie) | Tuhon |
| 2009 | The Boys of Ghost Town | Father |
| 2009 | Cowboy Dreams | Lobo |
| 2009 | RuPaul: Reinas del drag (serie) | Self - Special Guest / Big Daddy |
| 2008 | Jake's Corner | Clint |
| 2008 | Hijos de la anarquía (serie) | Romero 'Romeo' Parada |
| 2008 | Alone in the Dark II: El regreso de las sombras | Perry |
| 2008 | Ranchero | Capone |
| 2008 | El Superstar: The Unlikely Rise of Juan Frances | E.J. |
| 2008 | The Wendy Williams Show (serie) | Self |
| 2008 | Railroad to Hell: A Chinaman's Chance | Manolo |
| 2008 | El Espectacular Spider-Man (serie) | Ox (voice) |
| 2008 | Valley of Angels | Hector |
| 2008 | Toxic | Antoine |
| 2008 | D.O.P.E. - Death Or Prison Eventually | Narrator |
| 2008 | Breaking Bad (serie) | Tortuga |
| 2008 | Necessary Evil | Barro |
| 2007 | La caldera del infierno | Fury |
| 2007 | On Bloody Sunday | The Ref |
| 2007 | Phineas y Ferb (serie) | Venom (voice) |
| 2007 | Último aviso (serie) | Felipe Vega |
| 2007 | Fuerzas (Des)armadas | Carlos Santana |
| 2007 | Hijos de la noche (serie) | Pacha Kamaq |
| 2007 | El Tigre: las aventuras de Manny Rivera (serie) | — |
| 2007 | Tim and Eric Awesome Show, Great Job! (serie) | Criminal |
| 2006 | 7 Mummies | Apache |
| 2006 | Snoop Dogg's Hood of Horror | Derelict |
| 2006 | Jack's Law | Jack Santos |
| 2006 | Heist (serie) | — |
| 2006 | Top Chef (serie) | Himself - Guest Judge |
| 2006 | Propensity | Roy |
| 2006 | Tennis Anyone? | Hector |
| 2006 | Living the Dream | Chuck |
| 2005 | Bones (serie) | Bishop Edward Galano |
| 2005 | Pesadilla en la cocina (serie) | Self |
| 2005 | La maldición de El Charro | El Charro (Voice) |
| 2005 | Champion | Self |
| 2005 | Padre made in USA (serie) | Mexican Thugs (voice) |
| 2005 | Unscripted (serie) | Self |
| 2004 | Lost (Perdido) | Edward James Archer |
| 2004 | Mujeres desesperadas (serie) | Hector Ramos |
| 2004 | Stargate Atlantis (serie) | Omal |
| 2003 | Kingpin (serie) | — |
| 2002 | Beat the Devil | Bob |
| 2002 | Spy Kids 2: La isla de los sueños perdidos | Machete |
| 2002 | Monk (serie) | Spyder Rudner |
| 2002 | George Lopez (serie) | — |
| 2002 | Do It for Uncle Manny | Pedro |
| 2001 | Alias (serie) | Emilio Vargas |
| 2001 | Bubble Boy (El Chico de la Burbuja) | Slim |
| 2001 | The Hire (serie) | Bob |
| 2001 | Grounded for Life (serie) | — |
| 2001 | Skippy | Hitman |
| 2000 | Aqua Teen Hunger Force (serie) | Dewey (voice) |
| 2000 | Animal Factory | Vito |
| 2000 | The District (serie) | Self |
| 2000 | Operación Reno | Jumpy |
| 1999 | Abierto hasta el amanecer 3: La hija del verdugo | Razor Charlie |
| 1999 | Van Damme's Inferno | Johnny Six Toes |
| 1999 | Futurama (serie) | Doblando Rodriguez (voice) |
| 1999 | Padre de familia (serie) | (voice) |
| 1999 | Soundman | Duce's Father |
| 1998 | Point Blank | Wallace |
| 1998 | Asesinos de reemplazo | Collins |
| 1997 | Brooklyn South (serie) | Louis - Hertz's Bodyguard |
| 1997 | El rey de la colina (serie) | Enrique (voice) |
| 1997 | Dilemma | Rudy Salazar |
| 1997 | Renegados 2: Los locos | Manuel Batista |
| 1996 | El jaguar | Kumare |
| 1994 | High Tide (serie) | Tattooist |
| 1994 | Contra el muro | Luis |
| 1994 | Vanishing Son (serie) | Out-of-Breath Man |
| 1993 | Policías de Nueva York (serie) | Gabriel mota |
| 1993 | Expediente X (serie) | Cesar Ocampo |
| 1993 | Fallen Angels (serie) | Boxer |
| 1993 | Walker Texas Ranger (serie) | Joe Lopez |
| 1992 | Renegado (serie) | Freddie |
| 1991 | Tensión límite | Spider |
| 1991 | Reasonable Doubts (serie) | Cholo #2 |
| 1991 | Doublecrossed | Lito |
| 1990 | Guerra contra las drogas: La historia de Camarena (serie) | Gabriel |
| 1989 | Los vigilantes de la playa (serie) | Carlos Urueta |
| 1987 | Jake y el gordo (serie) | Mumbling Prisoner |
| 1987 | Penitenciaria III | See Veer |
| 1975 | Saturday Night Live (serie) | Self - Cameo (uncredited) |
| 1972 | The Price Is Right (serie) | Self |
