| 2024 | Unholy Trinity | St. Christopher |
| 2024 | Noche de combate: el atraco del millón de dólares (serie) | Frank Moten |
| 2024 | Garfield: La película | Vic (voice) |
| 2024 | Damaged | Dan Lawson |
| 2023 | The Marvels | Nick Fury |
| 2023 | Reunidos: Así se hizo Invasión secreta | Self - 'Nick Fury' |
| 2023 | El arte de matar | Gordon |
| 2023 | Invasión secreta (serie) | Nick Fury |
| 2023 | Marvel's Moon Girl y Dinosaurio Diabólico (serie) | Nick Fury (voice) |
| 2022 | The Jennifer Hudson Show (serie) | — |
| 2022 | Un héroe samurai: La leyenda de Hank | Jimbo (voice) |
| 2022 | Los últimos días de Ptolemy Grey (serie) | Ptolemy Grey |
| 2022 | JANET JACKSON. (serie) | Self |
| 2021 | An Audience with Adele | Self |
| 2021 | La protegida | Moody |
| 2021 | ¿Qué pasaría si...? (serie) | Nick Fury (voice) |
| 2021 | El Otro Guardaespaldas 2 | Darius Kincaid |
| 2021 | Spiral: Saw | Marcus Banks |
| 2021 | Estados Unidos: La lucha por la libertad (serie) | Self |
| 2021 | LEYENDAS de Marvel Studios (serie) | Nick Fury (archive footage) (uncredited) |
| 2020 | A la mierda el 2020 | Dash Bracket |
| 2020 | Esclavos (serie) | Self |
| 2020 | Enslaved with Samuel L Jackson | Presenter |
| 2020 | Staged (serie) | Sam |
| 2020 | Some Good News (serie) | Voice Over |
| 2020 | El banquero | Joe Morris |
| 2020 | Con todos los honores | Takoda |
| 2019 | Las películas que vimos (serie) | Self (archive footage) |
| 2019 | Tamron Hall (serie) | Invitado especial |
| 2019 | Spider-Man: Lejos de casa | Nick Fury |
| 2019 | Shaft | John Shaft |
| 2019 | Capitana Marvel | Nick Fury |
| 2019 | Glass (Cristal) | Elijah Price / Mr. Glass |
| 2018 | Los Increíbles 2 | Lucius Best / Frozone (voice) |
| 2017 | Tienda de unicornios | The Salesman |
| 2017 | El Otro Guardaespaldas | Darius Kincaid |
| 2017 | Carpool Karaoke: La serie (serie) | Self |
| 2017 | Creating a King: Summoning a God | Self |
| 2017 | Kong: La isla calavera | Lieutenant Colonel Preston Packard |
| 2017 | Smokey Robinson: The Library of Congress Gershwin Prize for Popular Song | Host |
| 2017 | No soy un negrata | Narrator (voice) |
| 2017 | xXx: Reactivated | Agent Augustus Gibbons |
| 2016 | Eating You Alive | Self |
| 2016 | El hogar de Miss Peregrine para niños peculiares | Barron |
| 2016 | Conexión Mortal | Thomas 'Tom' McCourt |
| 2016 | La leyenda de Tarzán | George Washington Williams |
| 2015 | Los odiosos ocho | Major Marquis Warren |
| 2015 | Chi-Raq | Dolmedes |
| 2015 | The Late Show with Stephen Colbert (serie) | Self |
| 2015 | Hollywood en primer plano (serie) | Self |
| 2015 | Barely Lethal | Hardman |
| 2015 | Caza mayor | US President William Alan Moore |
| 2015 | Kingsman: Servicio secreto | Valentine |
| 2014 | Variety Studio: Actors on Actors (serie) | Self |
| 2014 | Life's Essentials with Ruby Dee | Self |
| 2014 | Kite | Lieutenant Karl Aker |
| 2014 | Capitán América: El soldado de invierno | Nick Fury |
| 2014 | The Tonight Show Starring Jimmy Fallon (serie) | Self |
| 2014 | Duda razonable | Clinton Davis |
| 2014 | Face of Unity | Self |
| 2013 | Oldboy | Chaney |
| 2013 | Marvel Agentes de S.H.I.E.L.D. (serie) | Nick Fury |
| 2013 | Everything Is Samuel L. Jackson's Fault | Self |
| 2013 | Turbo | Whiplash (voice) |
| 2013 | Circus Halligalli (serie) | — |
| 2012 | Django desencadenado | Stephen |
| 2012 | Quentin Tarantino: 20 Years of Filmmaking | Self |
| 2012 | Eddie Murphy: One Night Only | Self |
| 2012 | The Avengers: A Visual Journey | Self |
| 2012 | Zambezia | Tendai (voice) |
| 2012 | Finding Your Roots (serie) | Self |
| 2012 | Furia (The Samaritan) | Foley |
| 2012 | Conociendo el mal | Richie |
| 2011 | Young Jeezy: A Hustlerz Ambition | Narrator |
| 2011 | Arena (Combate mortal) | Logan |
| 2011 | Prohibition (serie) | Reader (voice) |
| 2011 | The Jonathan Ross Show (serie) | Self |
| 2011 | Dynamo: El mago (serie) | Self |
| 2011 | Go the F**k to Sleep | Narrator (voice) |
| 2011 | Grandes felinos africanos: el reino del coraje | Narrator (voice) |
| 2011 | El límite del atardecer | Black |
| 2010 | Quantum Quest: A Cassini Space Odyssey | Fear (voice) |
| 2010 | Los otros dos | P.K. Highsmith |
| 2010 | Amenazados | Henry Harold 'H' Humphries |
| 2010 | Iron Man 2 | Nick Fury |
| 2010 | In the Land of the Free... | Narrator |
| 2009 | Madres e hijas | Paul |
| 2009 | Afro Samurai: Resurrection | Afro / Ninja-Ninja (voice) |
| 2009 | Watch What Happens Live with Andy Cohen (serie) | Invitado especial |
| 2009 | Alan Carr: Chatty Man (serie) | Self |
| 2009 | Uneven Fairways | Narrator |
| 2008 | The Spirit | Octopus |
| 2008 | Soul Men | Louis Hinds |
| 2008 | Star Wars: The Clone Wars (serie) | Mace Windu (voice) (archive sound) |
| 2008 | Protegidos por su enemigo | Abel Turner |
| 2008 | The War (serie) | Narrator (voice) |
| 2008 | Jumper | Roland |
| 2007 | Cleaner | Tom Cutler |
| 2007 | Respect Yourself: The Stax Records Story | Narrator |
| 2007 | Movida en el Polo | Narrator (voice) |
| 2007 | 1408 | Gerald Olin |
| 2007 | The Graham Norton Show (serie) | Self |
| 2007 | Afro Samurai (serie) | Afro Samurai / Ninja Ninja (voice) |
| 2006 | Black Snake Moan | Lazarus |
| 2006 | Regreso al infierno | William Marsh |
| 2006 | Mais Bastidores de Hollywood | Self |
| 2006 | Serpientes en el Avión | Neville Flynn |
| 2006 | 50 Films to See Before You Die | Self |
| 2006 | The Henry Rollins Show (serie) | — |
| 2006 | El color del crimen | Lorenzo Council |
| 2006 | Honor Deferred | Narrator |
| 2005 | Iconoclasts (serie) | Self |
| 2005 | The Boondocks (serie) | — |
| 2005 | The Colbert Report (serie) | — |
| 2005 | El jefe | Derrick Vann |
| 2005 | Extras (serie) | Samuel L. Jackson |
| 2005 | Coach Carter The Man Behind the Movie | Self |
| 2005 | La guerra de las galaxias. Episodio III: La venganza de los Sith | Mace Windu |
| 2005 | xXx2: Estado de emergencia | Agent Augustus Gibbons |
| 2005 | Mr. Increíble y amigos | Frozone (commentary voice) |
| 2005 | George Lucas: Creating an Empire | Presenter/Self |
| 2005 | Unforgivable Blackness: The Rise and Fall of Jack Johnson (serie) | — |
| 2005 | Entrenador Carter | Ken Carter |
| 2005 | The Late Late Show with Craig Ferguson (serie) | Self |
| 2004 | Los Increíbles | Lucius Best / Frozone (voice) |
| 2004 | Unforgivable Blackness: The Rise and Fall of Jack Johnson | Jack Johnson (voice) |
| 2004 | Un país en África | Langston Whitfield |
| 2004 | Cómo ser John Travolta | Self |
| 2004 | Giro inesperado | John Mills |
| 2004 | America Beyond the Color Line (serie) | Self |
| 2004 | Hollywood Legenden | Self |
| 2003 | The Ellen DeGeneres Show (serie) | Self |
| 2003 | S.W.A.T.: Los hombres de Harrelson | Sgt. Dan 'Hondo' Harrelson |
| 2003 | Basic | West |
| 2003 | Real Time with Bill Maher (serie) | Himself |
| 2003 | Jimmy Kimmel Live! (serie) | Self |
| 2002 | Jackie Brown: How It Went Down | Self |
| 2002 | xXx | Agent Augustus Gibbons |
| 2002 | Sin motivo aparente | Jack Friar |
| 2002 | The Art of Action: Martial Arts in the Movies | Self - Narrator |
| 2002 | La guerra de las galaxias. Episodio II: El ataque de los clones | Mace Windu |
| 2002 | Al límite de la verdad | Doyle Gipson |
| 2002 | Middle School Confessions | Host |
| 2001 | Negocios sucios | Elmo McElroy |
| 2001 | R2-D2: Beneath the Dome | Self |
| 2001 | The 100 Greatest Films | Self |
| 2001 | Los Proud (serie) | Joseph (voice) |
| 2001 | Comic Books & Superheroes | Self |
| 2001 | Muerte de un ángel | Romulus |
| 2000 | El protegido | Elijah Price |
| 2000 | Shaft: The Return | John Shaft |
| 2000 | Reglas de compromiso | Col. Terry L. Childers |
| 2000 | Any Given Wednesday | Willie Nutter |
| 2000 | Shaft: Still the Man | Self |
| 1999 | The Early Show (serie) | Self |
| 1999 | Deep Blue Sea | Russell Franklin |
| 1999 | From Star Wars to Star Wars: The Story of Industrial Light & Magic | Narrator, Host |
| 1998 | El violín rojo | Charles Morritz (Montréal) |
| 1998 | Negociador | Lt. Danny Roman |
| 1998 | Esfera | Dr. Harry Adams |
| 1997 | Jackie Brown | Ordell Robbie |
| 1997 | Eve's Bayou | Louis Batiste |
| 1997 | The View (serie) | Self |
| 1997 | 187, más mentes peligrosas | Trevor Garfield |
| 1997 | Leute heute (serie) | Self |
| 1997 | Sidney (Hard Eight) | Jimmy |
| 1996 | Memoria letal | Mitch Henessey |
| 1996 | Tiempo de matar | Carl Lee Hailey |
| 1996 | The Daily Show (serie) | Self |
| 1996 | Shaquille O'Neal: Larger than Life | Narrator (voice) |
| 1996 | The Search for One-eye Jimmy | Colonel Ron |
| 1996 | La gran esperanza blanca | Rev. Fred Sultan |
| 1995 | The Frank Skinner Show (serie) | Self |
| 1995 | Jungla de cristal: la venganza | Zeus Carver |
| 1995 | A Night to Die For | Self - Host |
| 1995 | El sabor de la muerte | Calvin Hart |
| 1995 | Instinto maternal | Kadar Lewis |
| 1995 | Happily Ever After: Fairy Tales for Every Child (serie) | The Mayor (voice) |
| 1994 | Pulp Fiction | Jules Winnfield |
| 1994 | Inside the Actors Studio (serie) | Self |
| 1994 | Fresh | Sam |
| 1994 | Hail Caesar | Mailman |
| 1994 | Contra el muro | Jamaal |
| 1994 | Asalto en West Point: el consejo de guerra a Johnson Whittaker | Richard Greener |
| 1993 | Late Night with Conan O'Brien (serie) | Invitado especial |
| 1993 | Infierno en Los Ángeles | Tat Lawson |
| 1993 | ¡Atrapen al ladrón! ¿Al Blanco o al Negro? | Andrew Sterling |
| 1993 | Con el arma a punto | Wes Luger |
| 1993 | Raw (serie) | — |
| 1992 | Ghostwriter (serie) | Reggie Jenkins |
| 1992 | HBO First Look (serie) | — |
| 1992 | The Tonight Show with Jay Leno (serie) | — |
| 1992 | Arenas Blancas | Greg Meeker |
| 1992 | Juice | Trip |
| 1991 | Dead and Alive: The Race for Gus Farace | Everett Hatcher |
| 1991 | Simplemente negocios | Monroe |
| 1991 | Jumpin' at the Boneyard | Mr. Simpson |
| 1991 | Fiebre salvaje | Gator Purify |
| 1990 | The Return of Superfly | Nate Cabot |
| 1990 | Tentación diabólica | Minister Garth |
| 1990 | Spike Lee & Company: Do It a Cappella | The Janitor |
| 1989 | Making 'Do the Right Thing' | Self |
| 1989 | Dead Man Out | Calvin Fredricks |
| 1988 | LIVE with Kelly and Mark (serie) | — |
| 1987 | Raw (El show de Eddie Murphy) | Eddie's Uncle |
| 1987 | Magic Sticks | Bum |
| 1987 | The Days and Nights of Molly Dodd (serie) | Brother Elvis |
| 1985 | Spenser, detective privado (serie) | — |
| 1978 | The Trial of the Moke | Johnson Whittaker |
| 1977 | The Displaced Person | Sulk |
| 1975 | Saturday Night Live (serie) | Self - Host |
| 1972 | Together for Days | Stan |
| 1971 | Great Performances (serie) | Self |
| 1953 | The Oscars (serie) | Self |
| 1952 | Today (serie) | Self |
| 1948 | Bambi-Verleihung (serie) | Self |
